|3-(3-((3,4-二甲氧基苯乙基)(甲基)氨基)丙基)-7,8-二甲氧基-4,5-二氢-1H-苯并[d]氮杂卓-2(3H)-酮|CsnPharm

CAS No.: 85175-67-3

3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one Catalog No. CSN12233

Synonyms: UL-FS-49 free base;UL-FS-49CL free base

Zatebradine is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner, with 92% inhibition of the hHCN1-mediated current at 10 uM.

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描述Zatebradine is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner, with 92% inhibition of the hHCN1-mediated current at 10 uM.
参考文献

[1] Matt L, Michalakis S, et al. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci. 2011 Jan;68(1):125-37.
[2] Gill CH, Randall A, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1902 mL
- 10.9511 mL
- 21.9022 mL
- 5 mM
- 0.4380 mL
- 2.1902 mL
- 4.3804 mL
- 10 mM
- 0.2190 mL
- 1.0951 mL
- 2.1902 mL

技术信息

CAS号

85175-67-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H36N2O5

运输

蓝冰

分子量

456.57

别名

UL-FS-49 free base;UL-FS-49CL free base

溶解度

DMSO	50.0 mg/mL (109.5 mM) warming
Ethanol	100.0 mg/mL (219.0 mM) warming

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3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one Catalog No. CSN12233

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